Tin powder-promoted one-pot synthesis of 3-spiro-fused or 3,3'-disubstituted 2-oxindoles.

نویسندگان

  • Juanjuan Wang
  • Danfeng Huang
  • Ke-Hu Wang
  • Xiansha Peng
  • Yingpeng Su
  • Yulai Hu
  • Ying Fu
چکیده

A convenient and efficient method for the constructions of 3-spirooxindole derivatives or 3,3'-disubstituted oxindoles has been developed from one-pot reactions of isatins, hydrazides or aromatic amines, 2-(bromomethyl)acrylic ester and tin powder in the presence of a catalytic amount of Brønsted or Lewis acid. The method avoids the use of toxic stannanes and allows easy operation. It is also proved that hydrazides are more favorable for intramolecular cyclization than amines.

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منابع مشابه

Synthesis of 3,3-disubstituted oxindoles by one-pot integrated Brønsted base-catalyzed trichloroacetimidation of 3-hydroxyoxindoles and Brønsted acid-catalyzed nucleophilic substitution reaction.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 14 40  شماره 

صفحات  -

تاریخ انتشار 2016